Muertoons

From BoardGameGeek.com:

In Muertoons, based on the animated series Muertoons and the 2003 card game Spooks, you get to follow the Muertoons characters to the Dia de los Muertos celebration — but only if you can get past grumpy Tio Rico, who hates the noise and lights of Dia de los Muertos and is making things difficult.

The Muertoons can show you the way to the event, but you need to do your part, too, by playing your numbered cards in the right order and discarding everything in your hand.; the first person to discard all their cards leads their friends to the Dia de los Muertos celebration!